(19)

(11)

EP 1 140 129 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99967363.5 (22) Date of filing: 15.12.1999

(51) International Patent Classification (IPC)7: A61K 38/00 (86) International application number: PCT/US9929/924 (87) International publication number: WO 0035/470 (22.06.2000 Gazette 2000/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.12.1998 US 212156 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: CALLAHAN, James, F. Philadelphia, PA 19111 (US) LAPING, Nicholas, J. West Chester, PA 19380 (US) WEINSTOCK, Joseph Wayne, PA 19087 (US) (74) Representative: Crump, Julian Richard John  FJ Cleveland & Company,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)