(19)

(11)

EP 1 140 146 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 00973762.8 (22) Date of filing: 21.10.2000

(51) International Patent Classification (IPC)7: A61K 38/22, A61K 39/395, A61K 47/00, C07H 21/04, C07K 14/705, C07K 16/28, C12N 15/63, C12N 15/70, C12N 15/85 (86) International application number: PCT/US0029/155 (87) International publication number: WO 0130/377 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.10.1999 US 161140 P (71) Applicant: ALEXION PHARMACEUTICALS, INC. New Haven, CT 06511 (US)	(72) Inventors: FODOR, William, L. Madison, CT 06443 (US) FAAS KNIGHT, Susan Old Lyme, CT 06371 (US) MATIS, Louis, A. Southport, CT 06490 (US) ROTHER, Russell, P. Cheshire, CT 06410 (US) (74) Representative: Maschio, Antonio  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)