(19)

(11)

EP 1 140 821 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99959602.6 (22) Date of filing: 14.12.1999

(51) International Patent Classification (IPC)7: C07D 207/26, C07D 207/28, C07D 207/48, C07D 211/74, C07D 211/78, A61K 31/4015, A61P 11/00 (86) International application number: PCT/GB9904/229 (87) International publication number: WO 0035/871 (22.06.2000 Gazette 2000/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.12.1998 GB 9827499 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)	(72) Inventor: SCHOFIELD, Christopher Joseph,Dyson Perrins Lab. South ParksRoad,Oxford OX1 3QY (GB) (74) Representative: Ellis-Jones, Patrick George Armine  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)