(19)

(11)

EP 1 140 913 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99965143.3 (22) Date of filing: 06.12.1999

(51) International Patent Classification (IPC)7: C07D 405/12, C07D 417/12, C07D 213/81, C07D 213/75, A61K 31/33, A61P 31/12 (86) International application number: PCT/US9928/892 (87) International publication number: WO 0034/269 (15.06.2000 Gazette 2000/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.12.1998 US 208540 (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)

(72) Inventors: BLOOM, Jonathan David Nyack, NY 10960 (US) DIGRANDI, Martin, Joseph Congers, NY 10920 (US) DUSHIN, Russell, George Garrison, NY 10524 (US) LANG, Stanley, Albert La Costa, CA 92009 (US) O'HARA, Bryan, Mark Norwood, NJ 07648 (US) (74) Representative: Walters, Philip Bernard William et al Wyeth Laboratories,Patents & Trade Marks Department,Huntercombe Lane South,Taplow Maidenhead,Berkshire SL6 0PH Maidenhead,Berkshire SL6 0PH (GB)