(19)

(11)

EP 1 140 946 A2

(12)

(88) Date of publication A3: 26.10.2000 (43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99964526.0 (22) Date of filing: 03.12.1999

(51) International Patent Classification (IPC)7: C07D 519/00, A61K 31/4985, A61K 31/437, A61K 31/4375, A61P 25/00, C07D 487/04, C07D 471/04, C07D 455/02 (86) International application number: PCT/EP9909/564 (87) International publication number: WO 0035/919 (22.06.2000 Gazette 2000/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.12.1998 GB 9827882 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: GASTER, Laramie Mary HarlowEssex CM19 5AW (GB) HEIGHTMAN, Tom Daniel HarlowEssex CM19 5AW (GB) (74) Representative: Waters, David Martin et al GlaxoSmithKline,Corporate Intellectual Property,Two New Horizons,Court Brentford,Middlesex TW8 9EP Brentford,Middlesex TW8 9EP (GB)