(19)

(11)

EP 1 140 991 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99966324.8 (22) Date of filing: 15.12.1999

(51) International Patent Classification (IPC)7: C07K 7/56, A61K 38/12, C07H 7/00 (86) International application number: PCT/US9929/914 (87) International publication number: WO 0035/944 (22.06.2000 Gazette 2000/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.12.1998 US 112434 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: RODRIGUEZ, John, Michael Indianapolis, IN 46260 (US) JAMISON, James, Andrew Indianapolis, IN 46254 (US) (74) Representative: Benson, John Everett et al J. A. Kemp & Co.,14 South Square,Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)