(19)

(11)

EP 1 141 243 A2

(12)

(88) Date of publication A3: 26.10.2000 (43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99961206.2 (22) Date of filing: 15.12.1999

(51) International Patent Classification (IPC)7: C12N 5/06, C12N 5/08, A61P 37/00 (86) International application number: PCT/GB9904/233 (87) International publication number: WO 0036/089 (22.06.2000 Gazette 2000/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.12.1998 GB 9827604 (71) Applicant: Lorantis Limited Cambridge CB2 4UL (GB)	(72) Inventors: LAMB, Jonathan, Robert Edinburgh EH19 1TZ (GB) DALLMAN, Margaret, Jane ActonLondon W3 6PF (GB) HOYNE, Gerard, Francis MussellburghMidlothian EH21 6UL (GB) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)