(19)

(11)

EP 1 141 263 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99951445.8 (22) Date of filing: 15.09.1999

(51) International Patent Classification (IPC)7: C12N 9/76, C12N 15/11, C12N 15/57, C12N 15/62, C12N 15/79, C12N 15/81 (86) International application number: PCT/US9921/047 (87) International publication number: WO 0017/332 (30.03.2000 Gazette 2000/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.09.1998 US 101213 P (71) Applicants: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US) UNIVERSITE LOUIS PASTEUR 67000 Strasbourg (FR)

(72) Inventors: HANQUIER, Jose, Michael Greenwood, IN 46142 (US) HERSHBERGER, Charles, Lee Greenfield, IN 46140 (US) DESPLANCQ, Dominique F-67100 Strasbourg (FR) LARSON, Jeffery, Lynn Indianapolis, IN 46260 (US) ROSTECK, Paul, Robert, Jr. Indianapolis, IN 46237 (US) (74) Representative: Denholm, Anna Marie  Eli Lilly and Company Limited,Lilly Research Center,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)