(19)

(11)

EP 1 141 270 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99967157.1 (22) Date of filing: 24.11.1999

(51) International Patent Classification (IPC)7: C12N 15/01, C12N 15/62, C12N 15/82, C12N 5/04, A01H 4/00, A01H 5/00, C12P 21/02, C12P 21/08 (86) International application number: PCT/US9928/104 (87) International publication number: WO 0032/761 (08.06.2000 Gazette 2000/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.11.1998 US 109973 P (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Philadelphia,Pennsylvania 19104-3147 (US)	(72) Inventors: ECKER, Joseph, R. Mullica Hill, NJ 08062 (US) SOLANO, Roberto,.Centro Nacional de Biot.-CSIC E-28049 Madrid (ES) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)