(19)

(11)

EP 1 141 284 A2

(12)

(88) Date of publication A3: 09.11.2000 (43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99960644.5 (22) Date of filing: 02.12.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, C12N 15/62, A61K 38/17 (86) International application number: PCT/US9928/565 (87) International publication number: WO 0037/638 (29.06.2000 Gazette 2000/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.12.1998 US 113296 P 08.03.1999 WO PCT/US05/00028 21.04.1999 US 130232 P 28.04.1999 US 131445 P 14.05.1999 US 134287 P 20.07.1999 US 144758 P 26.07.1999 US 145698 P 15.09.1999 WO PCT/US21/00090 15.09.1999 WO PCT/US21/00547 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: ASHKENAZI, Avi, J. San Mateo, CA 94402 (US) GODDARD, Audrey San Francisco, CA 94131 (US) GODOWSKI, Paul, J. Burlingame, CA 94010 (US) GURNEY, Austin, L. Belmont, CA 94002 (US) MARSTERS, Scot, A. San Carlos, CA 94070 (US) NAPIER, Mary, A. Hillsborough, CA 94010 (US) PITTI, Robert, M. El Cerrito, CA 94530 (US) WOOD, William, I. Hillsborough, CA 94010 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)