(19)

(11)

EP 1 141 289 A2

(12)

(88) Date of publication A3: 28.12.2000 (43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99966374.3 (22) Date of filing: 16.12.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, C12Q 1/68, G01N 33/53, C12N 15/62, C12N 15/11, A61K 39/395 (86) International application number: PCT/US9930/095 (87) International publication number: WO 0037/640 (29.06.2000 Gazette 2000/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.12.1998 US 113296 P 08.03.1999 WO PCT/US00/05028 02.06.1999 WO PCT/US12/00252 01.09.1999 WO PCT/US20/00111 15.09.1999 WO PCT/US21/00090 30.11.1999 WO PCT/US28/00313 30.11.1999 WO PCT/US28/00409 01.12.1999 WO PCT/US28/00301 02.12.1999 WO PCT/US28/00565 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: BOTSTEIN, David Belmont, CA 94002 (US) GODDARD, Audrey San Francisco, CA 94131 (US) GURNEY, Austin, L. Belmont, CA 94002 (US) HILLAN, Kenneth San Francisco, CA 94114 (US) LAWRENCE, David, A. San Francisco, CA 94122 (US) ROY, Margaret, Ann San Francisco, CA 94123 (US) WOOD, William, I. Hillsborough, CA 94010 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)