(19)

(11)

EP 1 141 316 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99965512.9 (22) Date of filing: 16.12.1999

(51) International Patent Classification (IPC)7: C12N 15/51, C07K 14/08, C12Q 1/68, G01N 33/68, A61K 39/29, C07K 16/10 (86) International application number: PCT/EP9910/179 (87) International publication number: WO 0037/650 (29.06.2000 Gazette 2000/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.12.1998 EP 98204313 20.01.1999 EP 99200167 (71) Applicant: Akzo Nobel N.V. 6824 BM Arnhem (NL)	(72) Inventors: YAP, Sing, Hiem B-3221 Nieuwrode (BE) VERSLYPE, C., J., C. B-3010 Kessel-Lo (BE) BOENDER, Pieter, Jacob NL-6522 KJ Nijmegen (NL) HELLINGS, J., A. NL-5283 AT Boxtel (NL) (74) Representative: Hermans, Franciscus G.M.  P.O. Box 20 5340 BH Oss 5340 BH Oss (NL)