(19)
(11) EP 1 141 320 A1

(12)

(43) Date of publication:
10.10.2001 Bulletin 2001/41

(21) Application number: 99967546.5

(22) Date of filing: 22.12.1999
(51) International Patent Classification (IPC)7: C12N 15/53, C12N 9/02, C12Q 1/26
(86) International application number:
PCT/US9930/707
(87) International publication number:
WO 0037/653 (29.06.2000 Gazette 2000/26)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.12.1998 US 113204 P

(71) Applicant: BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
Austin, Texas 78701 (US)

(72) Inventors:
  • RAMAN, C.S
    Houston,TX 77054 (US)
  • MASTERS, Bettie, Sue, S.
    San Antonio, TX 78232 (US)
  • MARTASEK, Pavel
    Praha 4-Chodov 14900 (CZ)
  • Roman, Linda, J.
    San Antonio, TX 78230 (US)
  • KRAL, Vladimir
    120 00 Prague 2 (CZ)
  • POULOS, Thomas,L.
    Irvine, CA 92612 (US)
  • LI, Huiying
    Irvine, CA 92614 (US)

(74) Representative: Michelet, Alain 
Cabinet Harlé et Phélip7, rue de Madrid
75008 Paris
75008 Paris (FR)

   


(54) STRUCTURAL BASIS FOR PTERIN FUNCTION IN NITRIC OXIDE SYNTHASE