(19)

(11)

EP 1 141 330 A2

(12)

(88) Date of publication A3: 16.11.2000 (43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99966407.1 (22) Date of filing: 17.12.1999

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 15/82, C12N 9/12, C12Q 1/68, C07K 14/415 (86) International application number: PCT/US9930/182 (87) International publication number: WO 0036/119 (22.06.2000 Gazette 2000/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.12.1998 US 112925 P (71) Applicant: E.I. DUPONT DE NEMOURS AND COMPANY Wilmington, DE 19808 (US)	(72) Inventors: ALLEN, Stephen, M. Wilmington, DE 19810 (US) KINNEY, Anthony, J. Wilmington, DE 19809 (US) MIAO, Guo-Hua Hockessin, DE 19707 (US) RAFALSKI, J., Antoni Wilmington, DE 19810 (US) SAKAI, Hajime Wilmington, DE 19803 (US) WENG, Zude Wilmington, DE 19809 (US) (74) Representative: Webber, Philip Michael  Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)