(19)

(11)

EP 1 141 394 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99962295.4 (22) Date of filing: 20.12.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, C07H 19/04, C07H 21/00 (86) International application number: PCT/GB9904/208 (87) International publication number: WO 0037/674 (29.06.2000 Gazette 2000/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.12.1998 GB 9827908 (71) Applicant: THE VICTORIA UNIVERSITY OF MANCHESTER Manchester M13 9PL (GB)	(72) Inventors: DOUGLAS, Kenneth Thomas Littleborough OL15 9LW (GB) BICHENKOVA, Elena Vladimirovna Manchester, M14 5SL (GB) (74) Representative: Atkinson, Peter Birch et al MARKS & CLERK,Sussex House,83-85 Mosley Street Manchester M2 3LG Manchester M2 3LG (GB)