(19)

(11)

EP 1 141 415 A1

(12)

(43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99968165.3 (22) Date of filing: 21.12.1999

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US9930/577 (87) International publication number: WO 0039/337 (06.07.2000 Gazette 2000/27)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.12.1998 US 220274 28.12.1998 US 222597 (71) Applicant: Rosetta Inpharmatics Inc. Kirkland, WA 98034 (US)	(72) Inventors: FRIEND, Stephen, H. Seattle, WA 98144 (US) STOUGHTON, Roland San Diego, CA 92103 (US) (74) Representative: Legg, Cyrus James Grahame et al ABEL & IMRAY,20 Red Lion Street London WC1R 4PQ London WC1R 4PQ (GB)