(19)

(11)

EP 1 144 440 A3

(12)

(88) Date of publication A3: 02.08.2001 (43) Date of publication A2: 17.10.2001 Bulletin 2001/42 (21) Application number: 00962668.0 (22) Date of filing: 14.09.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12N 15/63, C12N 5/10, C12P 21/02, C07K 16/28, G01N 33/53 (86) International application number: PCT/GB0003/541 (87) International publication number: WO 0119/854 (22.03.2001 Gazette 2001/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.09.1999 GB 9921833 17.03.2000 GB 0006545 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)

(72) Inventors: Hill, Jeffrey,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) Duckworth, David Malcolm,SmithKline Beecham Pha. Harlow,Essex CM19 5AW (GB) Farmer, Maurice,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) Pangalos, Menelas,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) (74) Representative: Crump, Julian Richard John  FJ Cleveland, 40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)

Remarks: WIPO A3 publication data is not currently available.