(19)

(11)

EP 1 144 450 A1

(12)

(43) Date of publication: 17.10.2001 Bulletin 2001/42 (21) Application number: 00905629.2 (22) Date of filing: 14.01.2000

(51) International Patent Classification (IPC)7: C07K 14/52, C12N 15/19, C07K 16/24, A61K 38/19, A61P 43/00 (86) International application number: PCT/US0001/015 (87) International publication number: WO 0042/070 (20.07.2000 Gazette 2000/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.01.1999 US 232427 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: CONKLIN, Darrell, C. Seattle, WA 98102 (US) COOPER, Emily Seattle, WA 98117 (US) JASPERS, Stephen, R. Edmonds, WA 98026 (US) LEHNER, Joyce, M. Seattle, WA 98103 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)