(19)

(11)

EP 1 144 622 A2

(12)

(88) Date of publication A3: 02.11.2000 (43) Date of publication: 17.10.2001 Bulletin 2001/42 (21) Application number: 00901580.1 (22) Date of filing: 17.01.2000

(51) International Patent Classification (IPC)7: C12N 15/11, C12N 15/12, C12Q 1/68 (86) International application number: PCT/EP0000/346 (87) International publication number: WO 0043/509 (27.07.2000 Gazette 2000/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.01.1999 GB 9901078 29.01.1999 GB 9902090 01.02.1999 GB 9902169 01.02.1999 GB 9902168 01.02.1999 GB 9902163 07.04.1999 GB 9907901 (71) Applicant: SmithKline Beecham Biologicals s.a. 1330 Rixensart (BE)	(72) Inventor: VINALS-BASSOLS, Carlota,SmithKline Beecham B-1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)