(19)

(11)

EP 1 144 648 A1

(12)

(43) Date of publication: 17.10.2001 Bulletin 2001/42 (21) Application number: 99968683.5 (22) Date of filing: 03.09.1999

(51) International Patent Classification (IPC)7: C12N 15/52, C12N 15/55, A61K 38/43 (86) International application number: PCT/US9920/287 (87) International publication number: WO 0014/248 (16.03.2000 Gazette 2000/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.09.1998 US 155210 (71) Applicant: Incyte Pharmaceuticals, Inc. Palo Alto, CA 94304 (US)	(72) Inventors: HILLMAN, Jennifer, L. Mountain View, CA 94040 (US) YUE, Henry Sunnyvale, CA 94087 (US) GUEGLER, Karl, J. Menlo Park, CA 94025 (US) CORLEY, Neil, C. Mountain View, CA 94040 (US) PATTERSON, Chandra Menlo Park, CA 94025 (US) TANG, Y., Tom San Jose, CA 95118 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)