(19)

(11)

EP 1 144 659 A2

(12)

(88) Date of publication A3: 16.11.2000 (43) Date of publication: 17.10.2001 Bulletin 2001/42 (21) Application number: 00900689.1 (22) Date of filing: 17.01.2000

(51) International Patent Classification (IPC)7: C12N 15/81, C12Q 1/68, C12N 15/11, C12N 1/19 (86) International application number: PCT/GB0000/111 (87) International publication number: WO 0042/204 (20.07.2000 Gazette 2000/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.01.1999 GB 9900919 (71) Applicant: ISIS INNOVATION LIMITED Oxford OX1 3UB (GB)	(72) Inventors: ARANDA FERNANDEZ, Agustin Oxford OX2 6UP (GB) GREGER, Ingo, Harald New York, NY 10016 (US) PROUDFOOT, Nicholas, Jarvis Oxford OX4 1AS (GB) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)