(19)

(11)

EP 1 146 868 A1

(12)

(43) Date of publication: 24.10.2001 Bulletin 2001/43 (21) Application number: 00900731.1 (22) Date of filing: 21.01.2000

(51) International Patent Classification (IPC)7: A61K 31/216, A61K 31/223, A61K 31/351, A61K 31/445, A61K 31/16, A61P 29/00 (86) International application number: PCT/GB0000/162 (87) International publication number: WO 0043/001 (27.07.2000 Gazette 2000/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.01.1999 GB 9901444 (71) Applicant: BRITISH BIOTECH PHARMACEUTICALS LIMITED CowleyOxford, OX4 5LY (GB)	(72) Inventors: AYSCOUGH, Andrew P.British Biot. Pharmaceu. Ltd. Oxford OX4 5LY (GB) WHITTAKER, MarkBritish Biotech Pharmaceu. Ltd. Oxford OX4 5LY (GB) (74) Representative: Walls, Alan James  British Biotech Pharmaceuticals Ltd.,Watlington Road Oxford OX4 5LY Oxford OX4 5LY (GB)