(19)

(11)

EP 1 146 898 A1

(12)

(43) Date of publication: 24.10.2001 Bulletin 2001/43 (21) Application number: 00907047.5 (22) Date of filing: 24.01.2000

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/395, A61K 48/00, A61P 25/00, A61P 25/08, A61P 25/16, A61P 25/24, A61P 25/28 // (C07K16/28, 14:705) (86) International application number: PCT/US0002/016 (87) International publication number: WO 0043/039 (27.07.2000 Gazette 2000/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.01.1999 US 116748 P 31.03.1999 US 127142 P (71) Applicant: During, Matthew John Philadelphia,Pennsylvania 19107 (US)	(72) Inventor: During, Matthew John Philadelphia,Pennsylvania 19107 (US) (74) Representative: Lock, Graham James et al Fry Heath & Spence,The Old College,53 High Street Horley,Surrey RH6 7BN Horley,Surrey RH6 7BN (GB)