(19)

(11)

EP 1 146 903 A1

(12)

(43) Date of publication: 24.10.2001 Bulletin 2001/43 (21) Application number: 99954963.7 (22) Date of filing: 15.10.1999

(51) International Patent Classification (IPC)7: A61K 39/395, C07K 16/00, C12Q 1/00, G01N 33/53, G01N 33/567, G01N 33/574 (86) International application number: PCT/US9924/176 (87) International publication number: WO 0023/109 (27.04.2000 Gazette 2000/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.10.1998 US 104510 P 25.02.1999 US 121624 P (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: LANDER, Arthur Laguna Beach, CA 92651 (US) KORC, Murray Irvine, CA 92697 (US) (74) Representative: HOFFMANN - EITLE  Patent- und RechtsanwälteArabellastrasse 4 81925 München 81925 München (DE)