(19)

(11)

EP 1 146 909 A1

(12)

(43) Date of publication: 24.10.2001 Bulletin 2001/43 (21) Application number: 00905923.9 (22) Date of filing: 03.02.2000

(51) International Patent Classification (IPC)7: A61K 48/00, A61K 31/00, C12N 15/63, G01N 33/50, G01N 33/567, G01N 33/574 (86) International application number: PCT/US0002/656 (87) International publication number: WO 0045/852 (10.08.2000 Gazette 2000/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.02.1999 US 118667 P (71) Applicant: The Johns Hopkins University Baltimore, MD 21202 (US)	(72) Inventors: PASTERNACK, Gary, R. Baltimore, MD 21210 (US) BAI, Jining Baltimore, MD 21212 (US) (74) Representative: Dean, John Paul et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)