(19)

(11)

EP 1 147 084 A1

(12)

(43) Date of publication: 24.10.2001 Bulletin 2001/43 (21) Application number: 00900723.8 (22) Date of filing: 11.01.2000

(51) International Patent Classification (IPC)7: C07D 211/54, C07D 401/10, A61K 31/445, A61P 25/00 (86) International application number: PCT/GB0000/153 (87) International publication number: WO 0043/362 (27.07.2000 Gazette 2000/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.01.1999 GB 9901147 (71) Applicant: MERCK SHARP & DOHME LTD. HoddesdonHertfordshire EN11 9BU (GB)

(72) Inventors: BLURTON, Peter HarlowEssex CM20 2QR (GB) BURKAMP, Frank HarlowEssex CM20 2QR (GB) CHENG, Susan, Koon-Fung HarlowEssex CM20 2QR (GB) FLETCHER, Stephen, RobertTerlings Park HarlowEssex CM20 2QR (GB) MACLEOD, Angus, Murray HarlowEssex CM20 2QR (GB) VAN NIEL, Monique, Bodil HarlowEssex CM20 2QR (GB) SPINKS, Daniel Lanarkshire ML1 5SH (GB) (74) Representative: Thompson, John Dr.  Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)