(19)

(11)

EP 1 147 182 A2

(12)

(88) Date of publication A3: 02.11.2000 (43) Date of publication: 24.10.2001 Bulletin 2001/43 (21) Application number: 00903263.2 (22) Date of filing: 12.01.2000

(51) International Patent Classification (IPC)7: C12N 9/00 (86) International application number: PCT/US0000/748 (87) International publication number: WO 0041/539 (20.07.2000 Gazette 2000/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.01.1999 US 229222 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: CONKLIN, Darrell, C. Seattle, WA 98102 (US) YAMAMOTO, Gayle Seattle, WA 98102 (US) GAO, Zeren Redmond, WA 98052 (US) JASPERS, Stephen, R. Edmonds, WA 98026 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)