1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS - Patent 1148878

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EP 1 148 878 A1

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(43)	Date of publication:
	31.10.2001 Bulletin 2001/44

(21)	Application number: 00908353.6

(22)	Date of filing: 26.01.2000

(51)	International Patent Classification (IPC)⁷: A61K 31/415, C07D 257/02, C07F 13/00

(86)	International application number:
	PCT/US0001/754

(87)	International publication number:
	WO 0043/004 (27.07.2000 Gazette 2000/30)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

26.01.1999 US 117253 P

(71)	Applicant: FOX CHASE CANCER CENTER
	PhiladelphiaPennsylvania 19111 (US)

(72)	Inventors:
	CHAPMAN, Donald J. Elkins Park, PA 19027 (US) SCHNEIDER, Richard F. Philadelphia, PA 19118 (US) ENGELHARDT, Edward L. Huntingdon Valley, PA 19006 (US)

(74)	Representative: Kiddle, Simon John et al
	Mewburn Ellis,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)

(54)	1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS