(19)
(11) EP 1 148 885 A1

(12)

(43) Date of publication:
31.10.2001 Bulletin 2001/44

(21) Application number: 00907132.5

(22) Date of filing: 07.02.2000
(51) International Patent Classification (IPC)7: A61K 31/70, A61K 45/00, A61N 1/30, A61N 1/00, C12M 1/42
(86) International application number:
PCT/US0002/831
(87) International publication number:
WO 0045/823 (10.08.2000 Gazette 2000/32)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 08.02.1999 US 118996 P
14.04.1999 US 129189 P

(71) Applicants:
  • CHIRON CORPORATION
    EmeryvilleCalifornia 94608-2916 (US)
  • Emed Corporation
    St. Paul, MN 55112 (US)

(72) Inventors:
  • SELBY, Mark
    San Francisco, CA 94131 (US)
  • GOLDBECK, Cheryl
    Moraga, CA 94556 (US)
  • PERTILE, Terry
    Blaine, MN 55449 (US)
  • WALSH, Robert
    Lakeville, MN 55144 (US)
  • LIU, Margaret, A.
    Lafayette, CA 94549 (US)
  • ULMER, Jeffery
    Danville, CA 94506 (US)

(74) Representative: Hallybone, Huw George et al
CARPMAELS AND RANSFORD43 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) ELECTRICALLY-MEDIATED ENHANCEMENT OF DNA VACCINE IMMUNITY AND EFFICACY IN VIVO