(19)

(11)

EP 1 149 166 A2

(12)

(88) Date of publication A3: 01.02.2001 (43) Date of publication: 31.10.2001 Bulletin 2001/44 (21) Application number: 00914458.5 (22) Date of filing: 27.01.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C12N 15/11, C12N 15/10, C07K 14/245 (86) International application number: PCT/US0002/200 (87) International publication number: WO 0044/906 (03.08.2000 Gazette 2000/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.01.1999 US 117405 P (71) Applicant: Elitra Pharmaceuticals, Inc. San Diego, CA 92121 (US)

(72) Inventors: ZYSKIND, Judith La Jolla, CA 92047 (US) OHLSEN, Kari, L. San Diego, CA 92117 (US) TRAWICK, John La Mesa, CA 91942 (US) FORSYTH, R., Allyn San Diego, CA 92109 (US) FROELICH, Jamie, M. San Diego, CA 92116 (US) CARR, Grant, J. Escondido, CA 92029 (US) YAMAMOTO, Robert, T. San Diego, CA 92131 (US) XU, H., Howard San Diego, CA 92131 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)