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(11)

EP 1 150 709 A2

(12)

(88) Date of publication A3: 15.03.2001 (43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 00928534.7 (22) Date of filing: 27.04.2000

(51) International Patent Classification (IPC)7: A61K 39/002, G01N 33/50, A61P 33/02, C12N 15/60, C12N 9/88, C12N 1/11, A61K 31/00, C07K 16/40, G01N 33/569, G01N 33/577, C12Q 1/68 (86) International application number: PCT/US0011/478 (87) International publication number: WO 0066/154 (09.11.2000 Gazette 2000/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.05.1999 US 132506 P (71) Applicants: Mcleod, Rima W. Chicago, IL 60637 (US) Roberts, Craig University of Strathclyde,Glasgow G4 0NR (GB) Roberts, Fiona Glasgow G12 0TW (GB) Johnson, Jennifer Stillwater, MN 55082 (US) Kirisits, Michael Chicago, IL 60657 (US) Ferguson, David Headington,Oxford OX3 9DU (GB) Lyons, Russell Glasgow G4 0NR (GB) Mui, Ernest Chicago, IL 60616 (US) Mack, Doug Riverside, IL 60546 (US) Samuel, Benjamin Chicago, IL 60657 (US) Gornicki, Piotri Chicago, IL 60615 (US) Zuther, Ellen 10405 Berlin (DE)

(72) Inventors: Mcleod, Rima W. Chicago, IL 60637 (US) Roberts, Craig University of Strathclyde,Glasgow G4 0NR (GB) Roberts, Fiona Glasgow G12 0TW (GB) Johnson, Jennifer Stillwater, MN 55082 (US) Kirisits, Michael Chicago, IL 60657 (US) Ferguson, David Headington,Oxford OX3 9DU (GB) Lyons, Russell Glasgow G4 0NR (GB) Mui, Ernest Chicago, IL 60616 (US) Mack, Doug Riverside, IL 60546 (US) Samuel, Benjamin Chicago, IL 60657 (US) Gornicki, Piotri Chicago, IL 60615 (US) Zuther, Ellen 10405 Berlin (DE) (74) Representative: Grund, Martin, Dr. et al Dr. Volker Vossius,Patentanwaltskanzlei,Holbeinstrasse 5 81679 München 81679 München (DE)