(19)
(11) EP 1 150 711 A1

(12)

(43) Date of publication:
07.11.2001 Bulletin 2001/45

(21) Application number: 00910070.2

(22) Date of filing: 02.02.2000
(51) International Patent Classification (IPC)7: A61K 39/112, A61K 39/02, A61K 39/108, A61K 39/106, A61K 39/102, A61K 39/10, A61K 39/095, C12N 1/20, C12N 1/21, C12N 1/36, C12N 15/74, A61P 31/04
// C12N1:20, C12R1:42
(86) International application number:
PCT/US0002/866
(87) International publication number:
WO 0045/840 (10.08.2000 Gazette 2000/32)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 02.02.1999 US 241951
05.05.1999 US 305603
01.02.2000 US 495614

(71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Oakland, California 94607-5200 (US)

(72) Inventors:
  • MAHAN, Michael, J.
    Santa Barbara, CA 93111 (US)
  • HEITHOFF, Douglas, M.
    Goleta, CA 93117 (US)
  • LOW, David, A.
    Goleta, CA 93117 (US)
  • SINSHEIMER, Robert, L.
    Santa Barbara, CA 93110 (US)

(74) Representative: Goldin, Douglas Michael 
J.A. KEMP & CO.14 South SquareGray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PATHOGENIC BACTERIAL INFECTION BASED ON THE ESSENTIAL ROLE OF DNA METHYLATION IN BACTERIAL VIRULENCE