(19)

(11)

EP 1 150 950 A2

(12)

(88) Date of publication A3: 19.10.2000 (43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 99968160.4 (22) Date of filing: 21.12.1999

(51) International Patent Classification (IPC)7: C07C 323/36, C07C 317/36, C07C 229/58, C07D 233/61, C07D 285/10, C07C 259/06, A61K 31/195, A61K 31/41 (86) International application number: PCT/US9930/491 (87) International publication number: WO 0041/505 (20.07.2000 Gazette 2000/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.01.1999 US 115876 P 02.03.1999 US 122583 P (71) Applicant: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US)	(72) Inventors: TECLE, Haile Ann Arbor, MI 48108 (US) BARRETT, Stephen, Douglas Livonia, MI 48154 (US) (74) Representative: Mansmann, Ivo et al Warner-Lambert Company,Patent Department,c/o Gödecke GmbH 79090 Freiburg 79090 Freiburg (DE)