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(11)

EP 1 150 979 A1

(12)

(43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 99943667.8 (22) Date of filing: 11.08.1999

(51) International Patent Classification (IPC)7: C07D 417/04, C07D 333/38, C07D 409/04, C07D 413/04, C07D 417/12, C07D 417/14, C07D 409/12, A61K 31/381, A61K 31/426, A61P 43/00 (86) International application number: PCT/US9918/065 (87) International publication number: WO 0047/578 (17.08.2000 Gazette 2000/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.02.1999 US 247062 (71) Applicant: 3-DIMENSIONAL PHARMACEUTICALS, INC. Exton, PA 19341 (US)

(72) Inventors: ILLIG, Carl, R. Phoenixville, PA 19460 (US) SUBASINGHE, Nalin, L. West Chester, PA 19380 (US) HOFFMAN, James, B. Ardmore, PA 19003 (US) WILSON, Kenneth, J. Exton, PA 19341 (US) RUDOLPH, M., Jonathan Doylestown, PA 18901 (US) MARUGAN, Juan, José Exton, PA 19341 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)