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(11)

EP 1 151 097 A1

(12)

(43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 00906280.3 (22) Date of filing: 04.02.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/285, A61K 39/102 (86) International application number: PCT/EP0000/887 (87) International publication number: WO 0047/737 (17.08.2000 Gazette 2000/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.02.1999 GB 9902880 (71) Applicant: SmithKline Beecham Biologicals s.a. 1330 Rixensart (BE)	(72) Inventors: RUELLE, Jean-Louis,SmithKline Beecham Biol. S.A. 1330 Rixensart (BE) THONNARD, Joelle,SmithKline Beecham Biol. S.A. 1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)