(19)

(11)

EP 1 151 107 A1

(12)

(43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 00910610.5 (22) Date of filing: 25.01.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C12N 1/21, C12Q 1/68, C07K 14/22, C07K 16/12, G01N 33/68, A61K 39/095, A61K 39/40, A61K 48/00 (86) International application number: PCT/EP0000/561 (87) International publication number: WO 0044/904 (03.08.2000 Gazette 2000/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.01.1999 GB 9902070 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS S.A. 1330 Rixensart (BE)	(72) Inventor: Thonnard, Joelle,SmithKline Beecham Bio. S.A. 1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)