(19)

(11)

EP 1 151 137 A1

(12)

(43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 00902755.8 (22) Date of filing: 09.02.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, C07K 14/47, A61K 35/00, C12N 5/10, C12N 15/85 (86) International application number: PCT/GB0000/414 (87) International publication number: WO 0047/768 (17.08.2000 Gazette 2000/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.02.1999 GB 9902919 (71) Applicant: ISIS INNOVATION LIMITED Oxford OX1 3UB (GB)	(72) Inventors: Knight, Julian Charles Headington,Oxford OX3 7BN (GB) Kwiatkowski, Dominic Peter Headington,Oxford OX3 9DU (GB) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)