(19)

(11)

EP 1 151 288 A1

(12)

(43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 00913428.9 (22) Date of filing: 10.02.2000

(51) International Patent Classification (IPC)7: G01N 27/327, G01N 33/543, C12Q 1/00 (86) International application number: PCT/US0003/485 (87) International publication number: WO 0047/983 (17.08.2000 Gazette 2000/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.02.1999 US 249532 (71) Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles, CA 90007-4344 (US)	(72) Inventor: MACPHEE, Robert D.,University S. California Los A ngeles, CA 90033 (US) (74) Representative: Viering, Jentschura & Partner  Postfach 22 14 43 80504 München 80504 München (DE)