(19)

(11)

EP 1 151 306 A1

(12)

(43) Date of publication: 07.11.2001 Bulletin 2001/45 (21) Application number: 00913451.1 (22) Date of filing: 11.02.2000

(51) International Patent Classification (IPC)7: G01N 33/68, G01N 33/543, G01N 30/72 (86) International application number: PCT/US0003/686 (87) International publication number: WO 0048/004 (17.08.2000 Gazette 2000/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.02.1999 US 119766 P 12.08.1999 US 148848 P (71) Applicant: Maxygen, Inc. Redwood City, CA 94063 (US)	(72) Inventors: RAILLARD, Sun, Ai Mountain View, CA 94043 (US) CHEN, Yong, Hong Foster City, CA 94404 (US) KREBBER, Claus Mountain View, CA 94043 (US) (74) Representative: Salka, Jeffrey  Maxygen ApS,Agern Allé 1,Danish Science Park 2970 Hoersholm 2970 Hoersholm (DK)