(19)

(11)

EP 1 152 771 A2

(12)

(88) Date of publication A3: 21.12.2000 (43) Date of publication: 14.11.2001 Bulletin 2001/46 (21) Application number: 00903870.4 (22) Date of filing: 17.02.2000

(51) International Patent Classification (IPC)7: A61K 39/39, C12N 5/06, C12N 5/08, A61K 39/00, A61K 35/14, C07K 14/705, C12N 15/12, C07K 16/28, G01N 33/50, A61P 37/04, A61P 37/06 // C07K19:00 (86) International application number: PCT/GB0000/559 (87) International publication number: WO 0048/631 (24.08.2000 Gazette 2000/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.02.1999 GB 9903664 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)	(72) Inventors: MACPHERSON, George Gordon,University of Oxford Oxford OX1 3RE (GB) WYKES, Michelle Niloufer,Mater Medical Res. Inst. South Brisbane, QLD 4152 (AU) (74) Representative: Irvine, Jonquil Claire  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)