(19)

(11)

EP 1 153 123 A2

(12)

(88) Date of publication A3: 08.03.2001 (43) Date of publication: 14.11.2001 Bulletin 2001/46 (21) Application number: 00903886.0 (22) Date of filing: 18.02.2000

(51) International Patent Classification (IPC)7: C12N 5/22, A61K 35/12, A61K 35/54, A61P 43/00 // C12N5:28 (86) International application number: PCT/GB0000/576 (87) International publication number: WO 0049/137 (24.08.2000 Gazette 2000/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.02.1999 GB 9903804 (71) Applicant: Intercytex Limited Manchester M13 9XX (GB)	(72) Inventors: ANDREWS, Peter,University of Sheffield Sheffield S10 2TN (GB) KEMP, Paul Romiley SK6 3JY (GB) (74) Representative: Davies, Jonathan Mark  Reddie & Grose16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)