ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYAL..............................*JDIM360 (Ver 1.5 21 Nov 2005) - 2999001/01153128CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120060118W10000000073deBibliographieenBibliographyfrBibliographieEP00903456.2200002092001080920031024enenen24973019990211US2006011820060320011114200146200511092005452005050920060118200603C12N 15/11 19900101AFI20000822BHEP A61K 31/7088 20000101ALI20000822BHEP A61P 35/00 20000101ALN20000822BHEP A61P 35/04 20000101ALN20000822BHEP deANTITUMOR-ANTISENSE SEQUENZEN GEGEN DIE R1 UND R2 KOMPONENTEN DER RIBONUKLEOTIDREDUKTASEenANTITUMOR ANTISENSE SEQUENCES DIRECTED AGAINST R1 AND R2 COMPONENTS OF RIBONUCLEOTIDE REDUCTASEfrSEQUENCES ANTISENS ANTITUMORALES CONTRE LES CONSTITUANTS R1 ET R2 DE LA RIBONUCLEOTIDE REDUCTASEWO-A-98/05769HUANG AIPING ET AL: "Ribonucleotide reductase R2 gene expression and changes in drug sensitivity and genome stability." CANCER RESEARCH, vol. 57, no. 21, 1 November 1997 (1997-11-01), pages 4876-4881, XP002053166 ISSN: 0008-5472MADER ROBERT M ET AL: "Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro." BIOCHEMICAL PHARMACOLOGY, vol. 54, no. 11, 1 December 1997 (1997-12-01), pages 1233-1242, XP002053167 ISSN: 0006-2952FAN HUIZHOU ET AL: "The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 24, 25 November 1997 (1997-11-25), pages 13181-13186, XP002137570 ISSN: 0027-8424ANAZODO M ET AL: "Relative levels of inhibition of p24 gene exüression by different 20-mer antisense oligonucleotid sequences targeting nucleotides +1129 to +1268 of the HIV1 gag genome: an analysis of mechanism" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 229, 1996, pages 305-309, XP002089438 ISSN: 0006-291X cited in the applicationWRIGHT, Jim, A.49 Golf Links DriveAurora, Ontario L4G 3V4CAYOUNG, Aiping H.201 Seniac RoadNorth York, Ontario M2R 1P3CAGeneSense Technologies Inc.02486782P012062EP ATM2 Meridian RoadToronto, Ontario M9W 4Z7CAMaschio, Antonio00077501D Young & Co 120 HolbornLondon EC1N 2DYGBATBECHCYDEDKESFIFRGBGRIEITLILUMCNLPTSEAL20010809LT20010809LV20010809MK20010809RO20010809SI20010809CA200000012020000209enWO200004773320000817200033