(19)

(11)

EP 1 155 009 A2

(12)

(88) Date of publication A3: 28.12.2000 (43) Date of publication: 21.11.2001 Bulletin 2001/47 (21) Application number: 00911868.8 (22) Date of filing: 18.02.2000

(51) International Patent Classification (IPC)7: C07D 307/22, A61K 31/351, A61P 31/18 (86) International application number: PCT/US0004/215 (87) International publication number: WO 0048/466 (24.08.2000 Gazette 2000/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.02.1999 US 120835 P (71) Applicants: Oklahoma Medical Research Foundation Oklahoma CityOklahoma 73104 (US) THE BOARD OF TRUSTEES OFTHE UNIVERSITY OF ILLINOIS Urbana, IL 61801 (US)	(72) Inventors: TANG, Jordan, J., N. Edmond, OK 73034 (US) GHOSH, Arun, K. River Forest, IL 60305 (US) (74) Representative: Miles, John Stephen  Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)