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EP 1 155 037 A1

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(43) Date of publication: 21.11.2001 Bulletin 2001/47 (21) Application number: 00905073.3 (22) Date of filing: 22.02.2000

(51) International Patent Classification (IPC)7: C07K 16/00, C07K 16/42, A61K 39/00, A61K 39/385, A61K 39/395, G01N 33/577, G01N 33/68, A61P 37/08 (86) International application number: PCT/EP0001/455 (87) International publication number: WO 0050/460 (31.08.2000 Gazette 2000/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.02.1999 GB 9904405 29.03.1999 GB 9907151 07.05.1999 GB 9910537 07.05.1999 GB 9910538 07.08.1999 GB 9918594 07.08.1999 GB 9918603 07.09.1999 GB 9921046 07.09.1999 GB 9921047 29.10.1999 GB 9925619 23.11.1999 GB 9927698 (71) Applicants: SmithKline Beecham Biologics SA 1330 Rixensart (BE) PEPTIDE THERAPEUTICS LIMITED Cambridge CB1 9PT (GB)

(72) Inventors: Dyson, Michael,Peptide Therapeutics Ltd. Cambridge CB1 9PT (GB) Friede, Martin,Corporate Intellectual Property Brentford,Middlesex TW8 9EP (GB) Greenwood, Judith,Peptide Therapeutics Ltd. Cambridge CB1 9PT (GB) Hewitt, Ellen,Peptide Therapeutics Ltd. Cambridge CB1 9PT (GB) Lamont, Alan,Peptide Therapeutics Ltd. Cambridge CB1 9PT (GB) Mason, Sean,Peptide Therapeutics Ltd. Cambridge CB1 9PT (GB) Randall, Roger,Peptide Therapeutics Ltd. Cambridge CB1 9PT (GB) Turnell, William Gordon,Peptide Therapeutics Ltd. Cambridge CB1 9PT (GB) Van Mechelen, Marcelle Paulette 1330 Rixensart (BE) Vinals Y De Bassols, Carlota 1330 Rixensart (BE) (74) Representative: Dalton, Marcus Jonathan William  SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)