(19)
(11) EP 1 155 115 A1

(12)

(43) Date of publication:
21.11.2001 Bulletin 2001/47

(21) Application number: 00911919.9

(22) Date of filing: 23.02.2000
(51) International Patent Classification (IPC)7: C12N 5/00, C12N 5/02
(86) International application number:
PCT/US0004/548
(87) International publication number:
WO 0050/569 (31.08.2000 Gazette 2000/35)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 24.02.1999 US 121482 P

(71) Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
Philadelpia, PA 19104-4268 (US)

(72) Inventors:
  • SANTOLI, Daniela
    Bryn Mawr, PA 19010 (US)
  • ROVERA, Giovanni
    Bryn Mawr, PA 19010 (US)
  • CESANO, Alessandra
    Philadelphia, PA 19103 (US)

(74) Representative: Hale, Stephen Geoffrey 
JY & GW Johnson,Kingsbourne House,229-231 High Holborn
London WC1V 7DP
London WC1V 7DP (GB)

   


(54) METHOD OF MODIFYING CYTOTOXIC CELLS AND USES THEREOF