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(11)

EP 1 157 106 A2

(12)

(88) Date of publication A3: 29.03.2001 (43) Date of publication: 28.11.2001 Bulletin 2001/48 (21) Application number: 00913665.6 (22) Date of filing: 29.02.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12N 5/10, A01K 67/027, C12P 21/02, C07K 16/28, C12Q 1/68, A61K 38/17, G01N 33/53 (86) International application number: PCT/US0005/153 (87) International publication number: WO 0052/161 (08.09.2000 Gazette 2000/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.03.1999 US 122080 P (71) Applicant: Incyte Pharmaceuticals, Inc. Palo Alto, CA 94304 (US)

(72) Inventors: LAL, Preeti Santa Clara, CA 95054 (US) YUE, Henry Sunnyvale, CA 94087 (US) HILLMAN, Jennifer, L. Mountain View, CA 94040 (US) LU, Dyung, Aina, M. San Jose, CA 95136 (US) BAUGHN, Mariah, R. San Leandro, CA 94577 (US) TANG, Y., Tom San Jose, CA 95118 (US) AZIMZAI, Yalda Hayward, CA 94545 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)