(19)

(11)

EP 1 157 111 A1

(12)

(43) Date of publication: 28.11.2001 Bulletin 2001/48 (21) Application number: 00911748.2 (22) Date of filing: 10.02.2000

(51) International Patent Classification (IPC)7: C12N 15/21 (86) International application number: PCT/US0003/381 (87) International publication number: WO 0052/167 (08.09.2000 Gazette 2000/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.03.1999 US 122499 P (71) Applicant: REGENERON PHARMACEUTICALS, INC. Tarrytown, NY 10591-6707 (US)	(72) Inventors: JONES, Pamela, F. Leeds LS16 7PE (GB) VALENZUELA, David, M. Yorktown Heights, NY 10598 (US) (74) Representative: Duckworth, Timothy John et al J.A. Kemp & Co.,14 South Square,Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)