(19)

(11)

EP 1 157 124 A1

(12)

(43) Date of publication: 28.11.2001 Bulletin 2001/48 (21) Application number: 00908783.4 (22) Date of filing: 24.02.2000

(51) International Patent Classification (IPC)7: C12P 19/30 (86) International application number: PCT/US0004/643 (87) International publication number: WO 0050/625 (31.08.2000 Gazette 2000/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.02.1999 US 121639 P (71) Applicant: INVITROGEN CORPORATION Carlsbad, CA 92008 (US)	(72) Inventors: SINGH, Jai, P. Sterling, VA 20165 (US) SMITH, Michael, D. Rockville, MD 20853 (US) LEVIN, Joshua, D. Olney, MD 20832 (US) (74) Representative: Schlich, George William  Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)