(19)

(11)

EP 1 157 126 A1

(12)

(43) Date of publication: 28.11.2001 Bulletin 2001/48 (21) Application number: 00911997.5 (22) Date of filing: 24.02.2000

(51) International Patent Classification (IPC)7: C12Q 1/00, C12Q 1/70, C12Q 1/66, C12N 7/00, C12N 5/00, C12N 5/02, G01N 33/554, A61K 38/00, C07H 21/02, C07H 21/04, C07H 21/00 (86) International application number: PCT/US0004/925 (87) International publication number: WO 0050/633 (31.08.2000 Gazette 2000/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.02.1999 US 121485 P (71) Applicant: The General Hospital Corporation Boston, MA 02110-2214 (US)	(72) Inventors: Seed, Brian Boston, MA 02114 (US) Ting, Adrian New York, NY 10128 (US) (74) Representative: Grund, Martin, Dr. et al Dr. Volker Vossius,Patentanwaltskanzlei,Holbeinstrasse 5 81679 München 81679 München (DE)