(19)

(11)

EP 1 159 004 A1

(12)

(43) Date of publication: 05.12.2001 Bulletin 2001/49 (21) Application number: 00913470.1 (22) Date of filing: 15.02.2000

(51) International Patent Classification (IPC)7: A61K 39/395 (86) International application number: PCT/US0003/878 (87) International publication number: WO 0048/632 (24.08.2000 Gazette 2000/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.02.1999 US 120128 P (71) Applicant: RUTGERS, THE STATE UNIVERSITY Piscataway, NJ 08854-8010 (US)	(72) Inventors: YURKOW, Edward, J. Clifton, NJ 07013 (US) MERMELSTEIN, Fred, H. Hillsborough, NJ 08876 (US) (74) Representative: Suèr, Steven Johannes et al Ablett & Stebbing,Caparo House,101-103 Baker Street London W1M 1FD London W1M 1FD (GB)